Development of a New Treatment in Orthodontics by Focusing on Clock Genes which are Regulated by microRNAs.

本研究的目的是通过关注由microrna调控的时钟基因来开发一种新的正畸治疗方法。然后我们研究了在正畸治疗中起重要作用的破骨细胞。具体来说，我们研究了在我们的研究中被认为对破骨细胞发生重要的八种mirna: let-7e、miR-21、miR-33、miR-155、miR-210、miR-223、miR-378和miR-1224。结果表明，破骨细胞分泌含有特定mirna的细胞外微泡，但它们不包含一整套细胞内mirna。

The aim of this study is to develop a new treatment in orthodontics by focusing on clock genes which are regulated by microRNAs. Then we investigated osteoclasts, which play an important role in orthodontics. Specifically, we investigated eight miRNAs deemed important for osteoclastogenesis in our study: let-7e, miR-21, miR-33, miR-155, miR-210, miR-223, miR-378, and miR-1224. The results suggest that osteoclasts secrete extracellular microvesicles containing specific miRNAs, but that they do not contain the entire set of intracellular miRNAs.