The study of the association between preterm - low birth weight delivery of the pregnant women with periodontitis and anti-phospholipid syndrome

牙周炎孕妇早产低体重儿与抗磷脂综合征的相关性研究

• 批准号: 23593068
• 负责人: MORI MARI
• 金额: $ 2.66万
• 依托单位: Health Sciences University of Hokkaido
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23593068/
• 关键词: 歯周病; 切迫早産; 抗リン脂質抗体症候群; 早産

In this study, we investigated whether there is the difference of the amount of anti-CL-beta 2 GPI complex antibodies of the pregnant women of anti-phospholipid syndrome due to the presence or absence if periodontopathic bacterial infection. The pregnant women of threatened premature delivery, received periodontal examination. The amounts of anti-CL-beta 2GPI complex antibodies in the serum were measured. Furthermore, the existence of the periodontopathic bacterium in a subject's periodontal pocket was examined. The periodontal tissue status of the pregnant women of anti-phospholipid syndrome improved by periodontal treatment, the amount of anti-CL-beta 2 GPI complex antibodies in the serum and periodontopathic bacterium in the periodontal pocket decreased. The pregnant woman has given birth to the normal weight child by full term birth. We suggested that there were associations between delivery outcomes and periodontal conditions of the anti-phospholipid syndrome pregnant women.

本研究旨在探讨抗磷脂综合征孕妇血清中抗CL-β 2 GPI复合物抗体的含量是否因有无牙周病细菌感染而存在差异。对先兆早产孕妇进行牙周检查。测量血清中抗CL-β 2GPI复合物抗体的量。此外，检查受试者牙周袋中牙周致病菌的存在。抗磷脂综合征孕妇经牙周治疗后牙周组织状况改善，血清中抗CL-β 2 GPI复合物抗体及牙周袋中牙周致病菌数量减少。孕妇已足月产下正常体重的婴儿。我们认为抗磷脂综合征孕妇的分娩结局与牙周状况之间存在关联。

项目成果

妊婦と歯周病―予防は?治療は?―

孕妇和牙周病 - 预防和治疗是什么？

• 发表时间: 2013
• 作者: Toshiyuki Nagasawa;Sintaro Shimizu;Takashi Kado;Tosiaki Komatsu;Tatsuhiro Hidaka;Satsuki Kato;Mari Mori and Yasushi Furuichi;長澤敏行,清水伸太郎,加藤幸紀,門貴司,日高竜宏,森真理,古市保志;清水伸太郎,長澤敏行,門貴司,小松寿明,日高竜宏,加藤幸紀,森真理古市保志;長澤敏行,清水伸太郎,日高竜宏,門貴司,加藤幸紀,森真理,古市保志;森真理
• 通讯作者: 森真理

歯周病が妊婦に与える影響と口腔内疾患の知識vol.4 No2

牙周病对孕妇影响及口腔疾病知识Vol.4 No2

• 发表时间: 2012
• 作者: Toshiyuki Nagasawa;Sintaro Shimizu;Takashi Kado;Tosiaki Komatsu;Tatsuhiro Hidaka;Satsuki Kato;Mari Mori and Yasushi Furuichi;長澤敏行,清水伸太郎,加藤幸紀,門貴司,日高竜宏,森真理,古市保志;清水伸太郎,長澤敏行,門貴司,小松寿明,日高竜宏,加藤幸紀,森真理古市保志;長澤敏行,清水伸太郎,日高竜宏,門貴司,加藤幸紀,森真理,古市保志;森真理;森真理
• 通讯作者: 森真理

Host-microbialco-evolutioninperiodontitisassociatedwithAggregatibacteractinomycetemcomitansinfection.

与聚集菌放线菌感染相关的牙周炎中的宿主微生物协同进化。

• DOI: 10.1016/j.job.2013.10.002
• 发表时间: 2014
• 期刊: JournalofOralBiosciences,
• 作者: 永田俊彦;二宮雅美;NagasawaT,ShimizuS,KatoS,NakatsukaY,KadoT,HidakaT,ShiraiK,MoriM,andFuruichi
• 通讯作者: NagasawaT,ShimizuS,KatoS,NakatsukaY,KadoT,HidakaT,ShiraiK,MoriM,andFuruichi

JP2型leukotoxin promoterを有するA.actinomycetemcomitans菌の解析

带有 JP2 型白细胞毒素启动子的放线放线菌分析

• 发表时间: 2012
• 作者: 永田俊彦;二宮雅美;NagasawaT,ShimizuS,KatoS,NakatsukaY,KadoT,HidakaT,ShiraiK,MoriM,andFuruichi;清水伸太郎,長澤敏行,門貴司,小松寿明,日高竜宏,加藤幸紀,森真理古市保志
• 通讯作者: 清水伸太郎,長澤敏行,門貴司,小松寿明,日高竜宏,加藤幸紀,森真理古市保志

Iron acquisition of A.actinomycetemcomitans with JP2 type leukotoxin isolated from Japanese periodontitis patients in Hokkaido

北海道日本牙周炎患者体内分离出的带有 JP2 型白细胞毒素的放线放线菌的铁获取

• 发表时间: 2012
• 作者: Toshiyuki Nagasawa;Sintaro Shimizu;Takashi Kado;Tosiaki Komatsu;Tatsuhiro Hidaka;Satsuki Kato;Mari Mori and Yasushi Furuichi
• 通讯作者: Mari Mori and Yasushi Furuichi