The onset diagnosis of the arteriosclerosis by periodontitis through the serum amyloid A.

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The purpose of this study was to elucidate the onset mechanism of atherosclerosis through periodontal disease induced serum amyloid A (SAA). Both of the serum SAA protein level and the aortic lipid deposition were increased significantly in the periodontitis model mouse which injected IL-6 into periodontal tissue. And the mRNA expressions of monocyte adhesion, migration factors and the SAA-receptor TLR2 were up-regulated significantly with SAA treatment for the endothelial cells. Furthermore, the expression of TLR2 was observed at the initial disease area of the aorta immunohistochemically in the mouse model.Therefore, these results suggest that periodontal disease induced SAA could deteriorate the atherosclerosis through TLR2, and a possibility that the onset diagnosis of arteriosclerosis could be performed according to the severity of the periodontal disease.