The expression system specific for the circadian center
The expression system specific for the circadian center
批准号:
23650177
负责人:
TAKUMI Toru
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
哺乳动物24小时昼夜节律振荡器定位于视交叉上核(SCN)。尽管近年来基因工程方法的进展提供了不同的区域特异性表达系统,但我们尚未获得SCN的特异性表达系统。目前的研究是试图建立一个使用不同启动子组合的scn特异性表达系统。
英文摘要
The mammalian oscillator for circadian rhythm with a period of 24 hours is localized in the suprachiasmatic nucleus (SCN). Although the recent advance in genetic engineering methods provide different region-specific expression system, we have not obtained the specific expression system in SCN. The present study is to try to establish a system of SCN-specific expression using a combination of different promoters.
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気分障害と概日時計を結ぶリチウム
锂与情绪障碍和生物钟有关
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[田渕克彦,張文欣,Nur Farehan Mohamed Asgar, Thomas C Sudhof, 重本隆一, 日置寛之, 内匠透]
通讯作者:
内匠透
時計遺伝子Per2と気分
时钟基因 Per2 和情绪
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Katsuhiko Tabuchi, Toru Takumi, Katsuhiko Tabuchi, Toru Takumi, 田渕 克彦, J. Myung et al (T. Takumi), Katsuhiko Tabuchi, 内匠透, 田渕克彦, 内匠透]
通讯作者:
内匠透
REV -ERBa and the clock gene machinery in mouse peripheral tissues: a possible role as a synchronizing hing
REV -ERBa 和小鼠外周组织中的时钟基因机制:作为同步铰链的可能作用
DOI:
--
发表时间:
2012
期刊:
J. Biol. Regul. Homeost. Agents
影响因子:
--
作者:
[Mazzoccoli, G., Cai, Y., Liu, M., Francavilla, M., Giuliani, F., Piepoli, A., Pazienza, V., Vinciguerra, M, Yamamoto, T. and Takumi, T]
通讯作者:
T
時計遺伝子 Per2 と気分
时钟基因 Per2 和情绪
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[倉本恵梨子, 大野幸, 藤山文乃, 古田貴寛, 雲財知, 田中康裕, 日置寛之, 金子武嗣, 内匠透]
通讯作者:
内匠透
Circadian Network of Bmal1
Bmal1 的昼夜节律网络
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Katsuhiko Tabuchi, Toru Takumi]
通讯作者:
Toru Takumi
共 17 条
Integrative analyses of circadian rhythms based on environment
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批准号:21390066
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.81万
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财政年份:2009
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负责人:TAKUMI Toru
-
依托单位:
Molecular mechanism of circadian oscillation by real-time rhythm monitoring
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批准号:18390093
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.5万
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财政年份:2006
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负责人:TAKUMI Toru
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依托单位:
Functional analysis of an RNA-binding protein, TLS, in neuronal dendrites.
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批准号:15590285
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2003
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负责人:TAKUMI Toru
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依托单位:
Genome-wide analyses of genes predominantly expressed in the mouse neocortex
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批准号:13670142
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2001
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负责人:TAKUMI Toru
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依托单位:
Measurement and Visualization of membrane potential by genetical manipul ati on.
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批准号:12557016
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.64万
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财政年份:2000
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负责人:TAKUMI Toru
-
依托单位:
Molecular mechanism of mammalian biological rhythms
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批准号:11670142
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.5万
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财政年份:1999
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负责人:TAKUMI Toru
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依托单位:
Generation of transgenic mice with arrythmia expressing a dominant-negative Isk
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批准号:10557004
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.76万
-
财政年份:1998
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负责人:TAKUMI Toru
-
依托单位:
海外基金