Development of hemodiagnostic methods for Alzheimer's disease using curcuimin derivatives

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We have developed a novel curcumin derivative (Shiga-Y5), that can exist in an equilibrium between keto and enol tautomers, with the enol form able to bind Aβ aggregates while the keto form cannot. Using Shiga-Y5, we developed a hemodiagnostic method to detect Aβ deposition in the Tg2576 mouse, a model of AD. When Shiga-Y5 injected into tail veins of Tg2576 and wild mice, a delayed decreaserate of Shiga-Y5 clearance was observed in Tg2576 mice in comparison to wild-type mice. The delayed clearance of Shiga-Y5 from the brain into blood reflected amounts of Aβ depositions in the brain.