Optical control of cell activity by introduction of photo-switching compound

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In this research subject, we made nano-sized complex, consisting of lipid, protein, and photo-switching molecules, and then the complex were introduced into cultivated cardiomyocyte in order to realize optical control of excitation of the cells. We found that the complexes were easily taken into the cells, and also were disassembled within the cell. As a result, the photo-switching molecules diffuse inside the cell, and then interact with cell membrane. In the research process, it was observed that structure of cell membrane was reversibly modified by the photo-sensitive substance. According to this result, it is assumed that the change of structure causes to increase membrane permeability of ions and other substances.