Three dimensional measurements of collagen structure in a vascular tissue subject to abnormal mechanical remodeling

本研究实验表明，使用二次谐波产生（SHG）的光学测量能够观察血管组织中胶原纤维的三维分布和取向。从组织标本的病理分析和脑动脉瘤的计算血流动力学分析推测，施加到血管组织的复杂应力场涉及用SHG测量的3D胶原结构。

This study experimental showed that the optical measurements using second harmonic generation (SHG) enable to observe the three dimensional distribution and orientation of collagen fibers in a vascular tissue. It was speculated from pathological analysis of the tissue specimen and the computational hemodynamic analysis of cerebral aneurysms that the complex stress field applied to the vascular tissue involves the 3D collagen structure measured with the SHG.