Molecular basis of epigenetic regulation by ultrasound

低强度脉冲超声(LIPUS)已被广泛用作骨折愈合的辅助手段。我们利用全球范围的基因表达分析技术，在单个20分钟的LIPUS(1.5 MHz，30 mW/cm2)处理小鼠成骨细胞后，发现了许多与骨形态相关的上调基因。这些结果将有助于进一步阐明成骨细胞LIPUS反应机制的分子基础。

Low-intensity pulsed ultrasound (LIPUS) has been used extensively as an adjuvant to fracture healing. We identified many up-regulated genes that were associated with bone morphology in mouse osteoblast cells treated with a single 20-min LIPUS (1.5 MHz, 30 mW/cm2) using global-scale gene expression analyzing technologies. These results obtained here should help to further clarify the molecular basis of the mechanisms of the LIPUS response in osteoblast cells.