Protective effects of exercise on muscle wasting caused by cachexia

本研究的目的是探讨运动对废用和癌症引起的肌肉萎缩的影响。恶病质导致肌肉横截面积和代谢酶减少，TNF-α和atrogin-1/MAFbx过表达。运动训练减轻肌肉萎缩和TNF-α和atrogin1 /MAFbx的过度表达。因此，运动训练减轻了与某些分解代谢条件有关的肌肉萎缩。这些结果为运动对肌肉萎缩的影响提供了进一步的证据。我们发现，不仅阻力运动方案，慢性耐力运动也可以通过下调TNF-α和间接下调atrogin-1/MAFbx基因表达来减轻废用和癌症引起的骨骼肌萎缩。

The purpose of this study is to investigate the effects of exercise on muscle wasting caused by disuse and cancer. Cachexia resulted in the reduction of muscle cross-sectional area and metabolic enzyme, and the overexpression of TNF-α and atrogin-1/MAFbx. Exercise training attenuates muscle atrophy and the overexpression of TNF-α and atrogin-1/MAFbx. Thus, exercise training attenuates muscle wasting associated with some catabolic conditions. These results provide further evidence for the effects of exercise on muscle wasting. It was found that not only resistance exercise protocols, but also chronic endurance exercises could attenuate skeletal muscle wasting induced by disuse and cancer through down-regulation of TNF-α and indirect down-regulation of atrogin-1/MAFbx gene expression.