Protective effects of exercise on muscle wasting caused by cachexia

运动对恶病质引起的肌肉萎缩的保护作用

• 批准号: 23650324
• 负责人: FUJINO Hidemi
• 金额: $ 2.41万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650324/
• 关键词: 筋萎縮; 運動; 悪液質; サイトカイン; カヘキシー; 炎症性サイトカイン; マイオカイン; リハビリテーション; 筋特異的リガーゼ

The purpose of this study is to investigate the effects of exercise on muscle wasting caused by disuse and cancer. Cachexia resulted in the reduction of muscle cross-sectional area and metabolic enzyme, and the overexpression of TNF-α and atrogin-1/MAFbx. Exercise training attenuates muscle atrophy and the overexpression of TNF-α and atrogin-1/MAFbx. Thus, exercise training attenuates muscle wasting associated with some catabolic conditions. These results provide further evidence for the effects of exercise on muscle wasting. It was found that not only resistance exercise protocols, but also chronic endurance exercises could attenuate skeletal muscle wasting induced by disuse and cancer through down-regulation of TNF-α and indirect down-regulation of atrogin-1/MAFbx gene expression.

本研究的目的是调查运动对废用性和癌症引起的肌肉萎缩的影响。恶病质导致肌肉横截面积和代谢酶减少，TNF-α和atrogin-1/MAFbx过度表达。运动训练减轻肌肉萎缩和TNF-α和atrogin-1/MAFbx的过度表达。因此，运动训练减弱与某些分解代谢条件相关的肌肉萎缩。这些结果为运动对肌肉萎缩的影响提供了进一步的证据。研究发现，抗阻运动和慢性耐力运动均可通过下调TNF-α和atrogin-1/MAFbx基因表达，减轻废用和癌症引起的骨骼肌萎缩。

项目成果

High-fat diet-induced reduction of peroxisome proliferator -activated receptor -γ coactivator -1αmessenger RNA levels and oxidative capacity in the soleus muscle of rats with metabolic syndrome

高脂饮食诱导代谢综合征大鼠比目鱼肌中过氧化物酶体增殖物激活受体-γ共激活物-1α信使RNA水平和氧化能力的降低

• 发表时间: 2012
• 期刊: Nutr Res
• 影响因子: 4.5
• 作者: Nagatomo F;Fujino H;Kondo H;Takeda I;Tsuda K;Ishihara A
• 通讯作者: Ishihara A

Antioxidant Supplementation to Prevent The Progression of Microangiopathy in Hindlimb Unloading-induced Atrophied Soleus Muscle in Rats

补充抗氧化剂可预防大鼠后肢卸荷引起的比目鱼肌萎缩的微血管病进展

• 发表时间: 2012
• 作者: Fujino H;Kanazashi M;Kondo H;Murakami S;Fujita N;Nagatomo F;Ishihara A
• 通讯作者: Ishihara A

Preventive effects of premodulated interferential and pulsed currents on muscle atrophy in deep layer of rat hindlimb muscle

预调干扰电流和脉冲电流对大鼠后肢肌肉深层肌肉萎缩的预防作用

• 发表时间: 2012
• 作者: Tanaka M;Fujita N;Fujino H
• 通讯作者: Fujino H

ラット後肢深層筋の廃用性萎縮に対する中周波及び低周波電気刺激の予防効果

中低频电刺激对大鼠后肢深层肌肉废用性萎缩的预防作用

• 发表时间: 2011
• 作者: Fujino H;Kanazashi M;Kondo H;Murakami S;Nagatomo F;Fujita N;Ishihara A;田中稔,藤田直人,藤野英己
• 通讯作者: 田中稔,藤田直人,藤野英己

Protective effects of isometric contraction using electrical stimulation on muscle atrophy

电刺激等长收缩对肌肉萎缩的保护作用

• 发表时间: 2011
• 作者: Fujita N;Fujino H
• 通讯作者: Fujino H