Development ofmedical countermeasures for disuse muscle atrophy and the protective effects of exercise preconditioning with nutritional supports

废用性肌肉萎缩的医学对策的制定以及营养支持运动预处理的保护作用

• 批准号: 22300189
• 负责人: FUJINO Hidemi
• 金额: $ 11.65万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22300189/
• 关键词: 筋萎縮; 運動; 栄養; 抗酸化; アスタキサンチン; ヌクレオプロテイン; フラボノイド; プレコンディショニング

：The reduction of skeletal muscle loss in pathological states, such as muscle disuse, has considerable effects in terms of rehabilitation and quality of life. Skeletal muscle and its microvasculature can exhibit remarkable plasticity in response to decreased functional demand, i.e., muscle disuse. In addition, disturbed redox signaling, due to increased production of reactive oxygen species (ROS), is an important regulator of cell signaling pathways that control both proteolysis and protein synthesis, and capillarity in skeletal muscle. Therefore, the purpose of this report is to investigate the effects of exercise with nutrition supports, e.g., anti-oxidant action, on atrophy and capillary regression in skeletal muscle. Exercise attenuated the atrophy in skeletal muscle. However, Exercise and loading could not attenuate the capillary regression in skeletal muscle. Anti-oxidant supplementation, i.e., astaxanthin, attenuated the capillary regression by decreasing the oxidative-stress. In addition, exercise combined with licorice flavonoid oil effectively reduced visceral adipose tissue, because exercise and licorice flavonoid oil enhanced the muscular and hepatic lipid metabolism, respectively. These results suggested that exercise combined with licorice flavonoid oil supplementation might be effective to decrease the risk from obesity. These results indicate that exercise combined with nutrition supports, i.e., nutrition supplementation, might be effective to prevent atrophy, capillary regression and metabolism disturbance in skeletal muscle.

：减少肌肉废用等病理状态下的骨骼肌损失，对康复和生活质量具有相当大的影响。骨骼肌及其微脉管系统可以表现出显着的可塑性，以应对功能需求的减少，即肌肉废用。此外，由于活性氧（ROS）产生增加，氧化还原信号传导受到干扰，是控制蛋白质水解和蛋白质合成以及骨骼肌毛细血管作用的细胞信号传导途径的重要调节因子。因此，本报告的目的是研究运动与营养支持（例如抗氧化作用）对骨骼肌萎缩和毛细血管退化的影响。运动减轻了骨骼肌的萎缩。然而，运动和负荷不能减弱骨骼肌中的毛细血管退化。抗氧化剂补充剂，即虾青素，通过减少氧化应激来减弱毛细血管的退化。此外，运动与甘草黄酮油结合可有效减少内脏脂肪组织，因为运动和甘草黄酮油分别增强肌肉和肝脏的脂质代谢。这些结果表明，运动与甘草类黄酮油补充剂相结合可能有效降低肥胖风险。这些结果表明，运动与营养支持相结合，即补充营养，可能有效预防骨骼肌萎缩、毛细血管退化和代谢紊乱。

项目成果

PGC-1a mRNA Level and Oxidative Capacity of the Plantaris Muscle in Rats with Metabolic Syndrome, Hypertension, and Type 2 Diabetes

代谢综合征、高血压和 2 型糖尿病大鼠跖肌 PGC-1a mRNA 水平和氧化能力

• 发表时间: 2011
• 期刊: Acta Histochemica et Cytochemica
• 影响因子: 2.4
• 作者: Nagatomo F;Fujino H;Kondo H;Gu N;Takeda I;Ishioka N;Tsuda K;Ishihara A
• 通讯作者: Ishihara A

下肢深層筋の廃用性筋萎縮に対する低周波及び中周波電気刺激の予防効果

中低频电刺激对下肢深层肌肉废用性肌萎缩的预防作用

• 发表时间: 2012
• 作者: Kazuki Nitta;Takashi Watanabe;Hiroki Saito;Eri Koike;Ryoko Takeda;田中稔，平山佑介，藤田直人，藤野英己
• 通讯作者: 田中稔，平山佑介，藤田直人，藤野英己

心不全による低栄養状態が速筋と遅筋における骨格筋内毛細血管の退行性変化に及ぼす影響

心力衰竭营养不良对快肌和慢肌骨骼肌毛细血管退行性变化的影响

• 发表时间: 2012
• 作者: 新田和樹;渡邉高志;齋藤広樹;小池英利;福留千弥，田中雅侑，藤田直人，藤野英己
• 通讯作者: 福留千弥，田中雅侑，藤田直人，藤野英己

運動生理学のニューエビデンス

运动生理学的新证据

• 发表时间: 2010
• 作者: 相澤勝治;宮村実晴
• 通讯作者: 宮村実晴

Regressed three-dimensional capillary network and inhibited angiogenic factors in the soleus muscle of non-obese rats with type 2 diabetes.

• DOI: 10.1186/1743-7075-8-77
• 发表时间: 2011-11-03
• 期刊: Nutrition & metabolism
• 影响因子: 4.5
• 作者: Kondo H;Fujino H;Murakami S;Nagatomo F;Roy RR;Ishihara A
• 通讯作者: Ishihara A