STUDIES ON FUNCTIONAL AND MORPHOLOGICAL CHANGES OF MECHANORECEPTOR IN ATROPHIC MUSCLE AFTER PASSIVE MOTION

萎缩肌被动运动后机械感受器功能和形态变化的研究

• 批准号: 12832064
• 负责人: FUJINO Hidemi
• 金额: $ 2.3万
• 依托单位: SUZUKA UNIVERSITY OF MEDICAL SCIENCE (2002)Kibi International University (2000-2001)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12832064/
• 关键词: MUSCLE MECHANORECEPTOR; MUSCLE ATROPHY; PASSIVE MOTION; SOLEUS MUSCLE; ANKLE JOINT; MUSCLE SPINDLE; RAT; FUNCTION; ヒラメ筋; 持続的他動運動; 伸長張力

The aim of the present study was to examine the responsiveness of skeletal muscle mechanoreceptors in atrophic muscle. The changes in mechanoreceptor activities during stimulation by ramp and hold stretching were studied in the rat soleus muscle with disuse atrophy. Ramp and hold stretching of the muscle was induced by passive motion of the ankle joint. Muscular atrophy was induced by hindlimb suspension or by immobilization with plaster cast at muscle shortening position for two weeks. The suspension and the immobilization resulted in a significant reduction of muscle weight (p<0.05). During the ramp stretching, the discharge frequency of the mechanoreceptors in healthy muscle showed a linear function. Similarly, the mechanoreceptor activities in the suspended hindlimb showed a linear function, but the discharge frequency rate became incrementally higher than in the healthy limb. In the immobilized hindlimb, the discharge frequency of the mechanoreceptors showed an exponential function. During hold stretching, the dynamic component of spindle afferent responses reduced significantly in the suspended and the immobilized hindlimbs. However, mechanoreceptor afferent responses were improved in these muscles after passive motion. These results indicate that following muscular atrophy achieved through two weeks of hindlimb immobilization, the function of the mechanoreceptors in skeletal muscle was changed. We suggest that awareness of changes of proprioceptive sensibility could provide a useful clue for advancing various therapeutic programs for rehabilitation of patients with atrophic muscles.

本研究的目的是检查萎缩肌肉中骨骼肌机械感受器的反应性。在废用性萎缩的大鼠比目鱼肌中研究了斜坡拉伸和保持拉伸刺激期间机械感受器活动的变化。肌肉的斜坡和保持拉伸是由踝关节的被动运动引起的。通过后肢悬吊或在肌肉缩短位置用石膏固定两周来诱导肌肉萎缩。悬浮和固定导致肌肉重量显着减少（p<0.05）。在斜坡拉伸过程中，健康肌肉中机械感受器的放电频率呈线性函数。同样，悬吊后肢的机械感受器活动呈现线性函数，但放电频率逐渐高于健康肢体。在固定的后肢中，机械感受器的放电频率呈指数函数。在保持伸展过程中，悬浮和固定后肢的纺锤体传入反应的动态成分显着减少。然而，被动运动后这些肌肉的机械感受器传入反应得到改善。这些结果表明，后肢固定两周后出现肌肉萎缩，骨骼肌机械感受器的功能发生了变化。我们认为，对本体感觉敏感性变化的认识可以为推进萎缩性肌肉患者康复的各种治疗方案提供有用的线索。

项目成果

FUJINO H, TAKEDA I, et al: "Effect of the stretching exercise on passive tension in atrophy muscle"J. Phys. Med. 14, in print. (2003)

FUJINO H，TAKEDA I，等：“伸展运动对萎缩肌肉被动张力的影响”J。

藤野英己, 武田 功, 他: "他動運動による筋伸長が萎縮筋の他動張力に及ぼす効果"理学療法学. 30巻(印刷中). (2003)

Hideki Fujino、Isao Takeda 等人：“被动运动延长肌肉对萎缩肌肉被动张力的影响”《物理治疗科学》第 30 卷（出版中）。

藤野英己, 武田 功, 他: "廃用性萎縮筋に対する筋伸長速度がメカノレセプターの活動性に及ぼす影響"運動療法と物理療法. 13巻(印刷中). (2003)

Hideki Fujino、Isao Takeda 等人：“肌肉伸展速度对废弃萎缩肌肉机械感受器活动的影响”运动疗法和物理疗法第 13 卷（出版中）。

藤野英己: "足関節ramp and hold stretchによるラットヒラメ筋メカノレセプターの活動様式"吉備国際大学保健科学部紀要. 6号(印刷中). (2001)

Hideki Fujino：“由于踝关节斜坡和保持伸展引起的大鼠比目鱼肌机械感受器的活动模式”吉备国际大学健康科学学院通报第 6 号（印刷中）。

FUJINO H, TAKEDA I, et al: "Influence of the stretching speed on mechano-receptor activities in atrophy muscle"Rigaku ryohogaku. 30, in print. (2003)

FUJINO H、TAKEDA I 等人：“拉伸速度对萎缩肌肉中机械感受器活动的影响”Rigaku ryohogaku。