The evaluation of exercise effect in muscle atrophy by development of muscular strength measuring device for mice

我们研制了一种无创、连续的小鼠足底最大屈曲扭矩测量装置，并探讨了抗阻运动(RE)促进肌肉萎缩恢复的组织学效应与功能效应的关系。结果，在比目鱼肌肌纤维横切区观察到RE引起的肌肉萎缩的组织学效应。但未能观察到足底屈曲扭矩的功能效应，提示差异是由于其他足底屈肌的组织学变化较小。然而，使用该设备已经连续地评估了肌肉萎缩或其恢复过程中的扭矩变化。

We developed the equipment which can noninvasively and sequentially measure the maximum Plantar-flexion torque of mouse, and investigated the relationship between histological effect and the functional effect of resistance exercise (RE) in facilitating recovery from the muscle atrophy. As a result, the histological effect from the muscle atrophy by RE was observed in the myofiber cross sectional area of the soleus muscle. However, the functional effect in plantar-flexion torque was not able to be observed, suggesting that the difference is due to the histological change of other plantar-flexior muscles were small. However, the torque change by muscle atrophy or its recovery process has been sequentially evaluated by using this equipment.