Functional analysis of circulating-microRNA in metabolic state of between distant organs

血液中含有大量循环中的miRNAs(c-miRNAs)。然而，与野生型小鼠相比，肥胖或限制卡路里是否会改变c-miRNAs的表达水平尚不清楚。为了阐明c-miRNAs的生理意义，观察到几个c-miRNAs的表达水平发生了变化，表明这些c-miRNAs参与了衰老和代谢紊乱。因此，血液中c-miRNAs的鉴定可能有助于生活方式疾病患者的诊断和治疗靶点的确定。

Blood contains large numbers of circulating miRNAs (c-miRNAs). However, it is not clear whether obesity- or calorie restriction alter the expression levels of c-miRNAs compared with wild-type mice. To elucidate the physiological significance of c-miRNAs, the expression levels of several c-miRNAs were observed to change, suggesting that these c-miRNAs are involved in aging and metabolic disorders. Thus, identification of c-miRNAs in the blood could be useful for diagnosis and for the identification of therapeutic targets in lifestyle disease patients.