The effects of mitochondrial complex II regulation onTumorigenesis

近年来，随着日本老龄化社会的到来，癌症的治疗和预防成为医疗领域的重要内容。编码线粒体复合体II亚基之一的SDHC基因作为一种癌症调控基因已受到重视。我们重点研究了SDHC基因突变对肿瘤发生和癌变的影响，分析了SDHC突变的自发转化细胞良恶性肿瘤过程中能量代谢和表观遗传组蛋白修饰的变化。

Recently, the cancer therapy and cancer prevention are very important in the medical field for the Japanese aging society. The SDHC gene which is encoding one of mitochondrial complex II subunit has been emphasized as a cancer regulatory gene. We focused on the effects of SDHC gene mutation on the tumorigenesis and carcinogenesis, and analyzed the energy metabolic and epigenetically histone modification changes in SDHC-mutated benign and malignant tumor process of spontaneous transformed cells.