The effects of mitochondrial complex II regulation onTumorigenesis
The effects of mitochondrial complex II regulation onTumorigenesis
批准号:
23650602
负责人:
ISHII Takamasa
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
Recently, the cancer therapy and cancer prevention are very important in the medical field for the Japanese aging society. The SDHC gene which is encoding one of mitochondrial complex II subunit has been emphasized as a cancer regulatory gene. We focused on the effects of SDHC gene mutation on the tumorigenesis and carcinogenesis, and analyzed the energy metabolic and epigenetically histone modification changes in SDHC-mutated benign and malignant tumor process of spontaneous transformed cells.
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ミトコンドリア酸化ストレスと角膜疾患
线粒体氧化应激与角膜疾病
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Naka K, Hoshii T, Tadokoro Y, Hirao A., Takamasa Ishii, M.Seno, 井垣達吏, Hirao A, 石井恭正]
通讯作者:
石井恭正
東海大学医学科伊勢原キャンパス 石井恭正
东海大学医学院 伊势原校区 石井康正
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Mitochondrial Superoxide-accelerated Age-dependent Corneal Cell Dysfunctions
线粒体超氧化物加速年龄依赖性角膜细胞功能障碍
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Matsuda Y, Ueda J, Ishiwata T., 石井恭正, Hirao A, 妹尾昌治, Takamasa Ishii]
通讯作者:
Takamasa Ishii
DOI:
10.1167/iovs.12-9573
发表时间:
2012-08-01
期刊:
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
影响因子:
4.4
作者:
[Onouchi, Hiromi, Ishii, Takamasa, Ishii, Naoaki]
通讯作者:
Ishii, Naoaki
The Mechanism of Longevity with Hormesis by the Low Dose X-irradiation in C. elegans
低剂量 X 射线照射线虫的长寿与毒物兴奋效应机制
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Yan T, Matsuda S, Prieto Vila M, Mizutani A. Murakami H, Seno M, Hirao A, Seitaro Hayashi]
通讯作者:
Seitaro Hayashi
共 25 条
The role of transcriptional repressor ZBTB20 on premature aging and energy metabolism
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批准号:18K06971
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2018
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负责人:ISHII Takamasa
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依托单位:
Analysis of age-related diseases with oxidative stress in mitochondrial ROS-inducible model mice
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批准号:22689012
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项目类别:Grant-in-Aid for Young Scientists (A)
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资助金额:$15.48万
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财政年份:2010
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负责人:ISHII Takamasa
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依托单位:
海外基金