Regulation mechanism by hydrogen sulfide anion of electrophilesignaling
Regulation mechanism by hydrogen sulfide anion of electrophilesignaling
批准号:
23651239
负责人:
AKAIKE Takaaki
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
在细胞对氧化应激的反应中,亲电试剂如8-硝基- cgmp是重要的信号介质。在本研究中,我们研究了硫化氢相关化合物与亲电试剂的反应机制,以揭示其在信号调节中的作用。结果,我们发现硫化氢相关化合物与8-硝基- cgmp反应生成8-SH-cGMP,并参与亲电信号的调控。
英文摘要
In the cellular response to oxidative stress, electrophiles suchas 8-nitro-cGMP function as important signal mediators. In this study, we examined thereaction mechanism of hydrogen sulfide-related compounds with electrophiles to revealits role in the signal regulation. As a result, we found that hydrogen sulfide-relatedcompounds react with 8-nitro-cGMP to produce 8-SH-cGMP, and are involved in the regulationof electrophile signaling.
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基礎の基礎
基础的基础
DOI:
--
发表时间:
2012
期刊:
細胞工学
影响因子:
--
作者:
[T.Nakamoto, T.Mikuriya, (他7名), 赤池孝章]
通讯作者:
赤池孝章
DOI:
10.1016/j.niox.2011.04.015
发表时间:
2011-08
期刊:
Nitric oxide : biology and chemistry
影响因子:
--
作者:
[H. Ihara;A. Ahtesham;T. Ida;S. Kasamatsu;Kouhei Kunieda;T. Okamoto;T. Sawa;T. Akaike]
通讯作者:
H. Ihara;A. Ahtesham;T. Ida;S. Kasamatsu;Kouhei Kunieda;T. Okamoto;T. Sawa;T. Akaike
Antioxidant effect of a nitratedcyclic nucleotide functioning as anendogenous electrophile.
作为内源性亲电子试剂的硝化环核苷酸的抗氧化作用。
DOI:
--
发表时间:
2011
期刊:
Curr Top MedChem.
影响因子:
--
作者:
[Sawa T, Ihara H, and Akaike T]
通讯作者:
and Akaike T
硫化水素の抗酸化機能と酸化ストレスバイオマーカー.
硫化氢和氧化应激生物标志物的抗氧化功能。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[藤井重元, 赤池孝章]
通讯作者:
赤池孝章
ドックスシグナル制御と酸化ストレスバイオマーカー
Dox 信号调节和氧化应激生物标志物
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[ボー・ラルフ(スウェーデン・アカデミー会員, ユーテボリ大学スウェーデン語学科教授), 茂木創, 赤池孝章]
通讯作者:
赤池孝章
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Study of the mechanism of biosynthesis of polysulfurated proteins coupled with translation
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批准号:16K15208
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.25万
-
财政年份:2016
-
负责人:AKAIKE Takaaki
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依托单位:
Novel signaling pathway of bacterial stress responses and host defense via autophagy
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批准号:26670207
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2014
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负责人:AKAIKE Takaaki
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依托单位:
Mechanism of intracellular formation of cysteine polysulfide and reactive oxygen species signaling
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批准号:25253020
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$29.79万
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财政年份:2013
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负责人:AKAIKE Takaaki
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依托单位:
Molecular mechanism of signal transduction by reactive oxygen species
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批准号:21390097
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.9万
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财政年份:2009
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负责人:AKAIKE Takaaki
-
依托单位:
Molecular regulatory mechanisms of NO analyzed by using nitronyl nitroxide
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批准号:15087207
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas
-
资助金额:$18.43万
-
财政年份:2003
-
负责人:AKAIKE Takaaki
-
依托单位:
Research on a novel mechanism for oxidative stress mediated by NO-induced nucleic acid nitration.
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批准号:15390107
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$2.69万
-
财政年份:2003
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负责人:AKAIKE Takaaki
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依托单位:
Development of analysis for all biologically relevant derivatives of NO
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批准号:12557010
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$3.01万
-
财政年份:2000
-
负责人:AKAIKE Takaaki
-
依托单位:
Research on microbial mutation and evolution involving oxidative stress
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批准号:12470038
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$6.59万
-
财政年份:2000
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负责人:AKAIKE Takaaki
-
依托单位:
Molecular Mechanisms of Redox-Regulation in Viral Pathogenesis
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批准号:09470046
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$3.71万
-
财政年份:1997
-
负责人:AKAIKE Takaaki
-
依托单位:
Viral Pathogenesis and Regulation Mechanism of Free Radicals in Host Responses : Role of Nitric Oxide
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批准号:07670347
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.47万
-
财政年份:1995
-
负责人:AKAIKE Takaaki
-
依托单位:
Involvement of virus infection in the pathogenesis of pulmonary fibrosis
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批准号:04670472
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
-
财政年份:1992
-
负责人:AKAIKE Takaaki
-
依托单位:
海外基金