Emergence of protein-like higher order structures and functions by dynamic reorganization of polypeptide side chains

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A polypeptide to which a functional group derived from an aldehyde was introduced via imine bond was prepared by the reaction of the aldehyde with amino groups of poly(L-lysine) having a small amount of hydrophilic side chains. The polypeptide was dissolved in methanol along with aldehydes with various functional groups, and shuffling of side chain functional groups based on dynamic exchange between imine and aldehyde was observed. Higher-order structure of the polypeptide was found to be changed with the side-chain shuffling.