Cancer cell selective magnetic nanoaprticles and application for hyperthermia treatment

癌细胞选择性磁性纳米粒子及其热疗应用

• 批准号: 23656013
• 负责人: ICHIYANAGI Yuko
• 金额: $ 2.5万
• 依托单位: Yokohama National University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23656013/
• 关键词: magnetic hypertnermia; nanoparticle; ac susceptibility; cancer; ferrites; relaxation loss; 磁性体; ハイパーサーミア; がん温熱療法; 交流磁化率; ナノテクノロジー; DDS; 局所構造; ナノ材料創成; 微粒子; 機能化; ナノ医療; がん

Magnetic nanoparticles encapsulated in amorphous SiO2 were prepared using our original wet chemical method. The cancer cell selective magnetic particles were developed by functionalization. Magnetization measurements were performed for various composition and particle size. AC magnetic susceptibility measurements were performed for samples, and particle composition, size were optimized for magnetic hyperthermia treatment.In vitro experiments to study the hyperthermia effects on cancerous cells were carried out and drastic effects were obtained.

采用湿化学法制备了包埋在无定形二氧化硅中的磁性纳米颗粒。通过功能化的方法制备了癌细胞选择性磁性颗粒。对不同的成分和颗粒大小进行了磁化测量。对样品进行了交流磁化率测量，优化了磁热处理的颗粒组成、大小，并进行了体外实验，研究了热疗对癌细胞的影响，取得了明显的效果。

项目成果

Study on increase in temperature of Co–Ti ferrite nanoparticles for magnetic hyperthermia treatment

纳米钴钛铁氧体磁热疗升温研究

• DOI: 10.1016/j.tca.2011.02.012
• 发表时间: 2012
• 期刊: Thermochimica Acta
• 影响因子: 3.5
• 作者: Y. Ichiyanagi;D. Shigeoka;Tomoyuki Hiroki;Toshiyuki Mashino;S. Kimura;A. Tomitaka;K. Ueda;Y. Takemura
• 通讯作者: Y. Takemura

Development of functional magnetic nanoparticles for biomedical application

生物医学应用功能性磁性纳米粒子的开发

• 发表时间: 2013
• 期刊: Proceedings of SPIE, Oxide-based Materials and Devices III
• 作者: 今井大地;石谷善博;王 新強;草部一秀;吉川明彦;西野 孝;Yuko Ichiyanagi
• 通讯作者: Yuko Ichiyanagi

Production of Fe3-xZnxO4 nanoparticles for agents in hyperthermia treatment

热疗制剂用 Fe3-xZnxO4 纳米粒子的制备

• 发表时间: 2013
• 期刊: Journal of Basic and Applied Physics
• 作者: H. Takeuchi;A. Kurokawa;T. Yanoh;S. Yano;K. Onuma;T. Kondo;K. Miike;T. Miyasaka;M. Hachisu;K. Mori and Y. Ichiyanagi
• 通讯作者: K. Mori and Y. Ichiyanagi

Functional Magnetic Nanoparticles for Hyperthermia and Imaging Agent

用于热疗和成像剂的功能性磁性纳米颗粒

• 发表时间: 2012
• 作者: Yuko Ichiyanagi

Development of functional magnetic nanoparticles for biomedical application, Photonic West, SPIE OPTO

开发用于生物医学应用的功能性磁性纳米粒子，Photonic West，SPIE OPTO

• 发表时间: 2012
• 作者: Yuko Ichiyanagi;Yuko Ichiyanagi
• 通讯作者: Yuko Ichiyanagi