Development of Novel Prostate Specific Membrane Antigen Targeting Probes for Prostate Cancer Imaging

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PCa (prostate cancer) is the most commonly diagnosed and the second leading cause of cancer-related deaths in men in the world. So, non-invasive diagnoses of PCa by imaging techniques have high clinical benefit. PSMA (Prostate Specific Membrane Antigen) is a noticeable target for PCa imaging. Ten~1,000-fold higher expression of PSMA have been reported in PCa than in normal prostate. Therefore, we started the research for developing novel PSMA imaging probes.[123I]IGLCE showed high stability, high affinity for PSMA, PSMA-specific high tumor uptake, and fast blood clearance. In the SPECT/CT study, [123I]IGLCE clearly distinguishedLNCaP tumors from PC-3 tumors. These results suggest that [123I]IGLCE can be a promising probe for PSMA imaging in future.