Reliability of CTP-derived CBF in relation to hemodynamic compromise in patients with steno-occlusive disease: a comparative study with PET

对于脑血管疾病患者的诊断，脑血流量（CBF）的测量为了解病理生理学和确定治疗策略提供了有价值的信息。在本研究中，为了研究CT灌注衍生CBF的可靠性，我们对大动脉狭窄或闭塞患者进行了PET作为CBF测量金标准的比较研究。研究了sSVD、dSVD和cSVD的反卷积方法与CBF估计的MTT依赖性的关系。与PET相比，cSVD导致对同侧与对侧CBF比的高估，尤其是在MTT区域。dSVD表现出较好的MTT依赖性，但在计算时间上存在实际问题。应发展对MTT依赖性较小、临床实用的新型反褶积技术。

For diagnosis of patients with cerebrovascular disease, measurements of cerebral blood flow (CBF) provide valuable information for understanding pathophysiology and determining therapeutic strategy. In the present study, to investigate reliability of CT perfusion-derived CBF we performed a comparative study for patients with major artery stenosis or occlusion with PET as a gold standard of CBF measurement. Deconvolution methods with sSVD, dSVD, and cSVD were investigated in relation to MTT dependence of CBF estimates. cSVD caused large overestimation of ipsilateral-to-contralateral CBF ratio compared to PET, especially in greatly-prolonged MTT regions. dSVD exhibits a better property of the MTT dependence, but remains with a practical problem on computational time. New deconvolution techniques with less MTT dependence and practical for clinical use should be developed.