Functional analysis of BRCA1/BAP1 complex

BRCA1/BAP1 复合物的功能分析

• 批准号: 23791504
• 负责人: NISHIKAWA Hiroyuki
• 金额: $ 2.66万
• 依托单位: St. Marianna University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791504/
• 关键词: 癌抑制遺伝子; 癌; 脱ユビキチン化; ガン抑制遺伝子

I went to the identification of proteins that bind to the BAP1 in the cell.It was possible to identify the interaction factor of 51 types. Histone chaperone protein, the chromatin remodeling association was found as multiple interacting factors and BAP1 in this experiment.

我去鉴定了细胞中与BAP 1结合的蛋白质。有可能鉴定出51种类型的相互作用因子。本实验发现组蛋白伴侣蛋白与BAP 1是一种相互作用的蛋白质。

项目成果

DNA相同組換え修復と乳癌

DNA同源重组修复与乳腺癌

• 发表时间: 2012
• 期刊: メディカルサイエンスダイジェスト
• 作者: 太田智彦;西川裕之
• 通讯作者: 西川裕之

HERC2 Interacts with Claspin and Regulates DNA Origin Firing and Replication Fork Progression

• DOI: 10.1158/0008-5472.can-11-0385
• 发表时间: 2011-09-01
• 期刊: CANCER RESEARCH
• 影响因子: 11.2
• 作者: Izawa, Naoki;Wu, Wenwen;Ohta, Tomohiko
• 通讯作者: Ohta, Tomohiko

A DNA-Damage Selective Role for BRCA1 E3 Ligase in Claspin Ubiquitylation, CHK1 Activation, and DNA Repair

• DOI: 10.1016/j.cub.2012.07.034
• 发表时间: 2012-09-25
• 期刊: CURRENT BIOLOGY
• 影响因子: 9.2
• 作者: Sato, Ko;Sundaramoorthy, Elayanambi;Venkitaraman, Ashok R.
• 通讯作者: Venkitaraman, Ashok R.

Recruitment of Phosphorylated NPM1 to Sites of DNA Damage through RNF8-Dependent Ubiquitin Conjugates

• DOI: 10.1158/0008-5472.can-10-0382
• 发表时间: 2010-09-01
• 期刊: CANCER RESEARCH
• 影响因子: 11.2
• 作者: Koike, Ayaka;Nishikawa, Hiroyuki;Ohta, Tomohiko
• 通讯作者: Ohta, Tomohiko