Neuroprotection using hydrogen sulfide donors : in the mice primary cultured neurons

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Paraplegia is a severe complication after the surgery of thoracic aorta anyrism. But the mechanism is unknown. We performed a study on mechanism of the neuroprotection with hydrogen sulfide after spinal cord ischemia, using the mice primary cultured neurons. We used sodium sulphide and GYY4137 as a hydrogen sulfide donor. However, the effect of neuroprotection for cultured neurons was weak. We seek the protein signals in the neurons with hydrogen sulfide attaching (sodium sulphide and GYY4137) by DNA micro array. However, no significant change was confirmed by DNA micro array.