The rule of LTB4/BLT1 signaling in the ischemia reperfusion injury of liver

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We have demonstrated that cardiac arrest damages hepatic parenchymal cell through the LTB4/BLT1 signaling. ALT level in WT, BLT1-/- and AA-861 treatment group were determined 24hr after CA/CPR. There were significant difference between WT and BLT1-/-, WT and AA861 treatment group in Male. Similarly, the ALT level of BLT1-/- was significantly reduced compared with WT in Female. These results suggested that blockade of LTB4/BLT1 signaling may suppress liver tissue damage through inhibiting effect of the neutrophil recruitment.