The association between TNF-α and apoptosis in urethral sphincter with aging

我们探讨了尿失禁机制与炎症因子（如TNF-α）与衰老之间的关系。在退休出血大鼠的实验中，随着生育后年龄的增长，尿道大陆功能明显下降，可以认为生育后年龄减少了尿道支持。另一方面，尿道内细胞外基质（extracellular matrix, ecm）的转录本随着年龄的增长而显著减少，但炎症细胞因子的转录本在年轻组和老年组之间没有显著变化。随着年龄的增长，ECM的减少可能会减弱尿道支撑系统的刚度和弹性，这可能是老年产妇SUI的一部分。

We explored the association between urinary continence mechanism and inflammatory cytokines (e.g. TNF-α) with aging. In the experiments using retired bleeder rat, urethral continent functions significantly decreased with aging after child-birth, and it has been considered that aging after child-birth attenuated urethral support. On the other hand, transcripts of extracellualr matrixs (ECMs) in urethra were significantly decreased with aging, although there were no significant changes in those of inflammatory cytokinesbetween young groups and aged groups. Reduction of ECM with aging might attenuate stiffness and elasticity of urethral support system, and may be a part of SUI in elderly, parous women.