The association between TNF-α and apoptosis in urethral sphincter with aging

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We explored the association between urinary continence mechanism and inflammatory cytokines (e.g. TNF-α) with aging. In the experiments using retired bleeder rat, urethral continent functions significantly decreased with aging after child-birth, and it has been considered that aging after child-birth attenuated urethral support. On the other hand, transcripts of extracellualr matrixs (ECMs) in urethra were significantly decreased with aging, although there were no significant changes in those of inflammatory cytokinesbetween young groups and aged groups. Reduction of ECM with aging might attenuate stiffness and elasticity of urethral support system, and may be a part of SUI in elderly, parous women.