The analysis of physiological function of FOXL2 in human ovary.

FOXL2在人类颗粒细胞和黄体细胞中的生理作用FOXL2是一个叉头转录因子基因，最近被证明是导致颗粒细胞瘤或原发卵巢衰竭的原因。FOXL2主要表达于眼周和卵巢颗粒细胞，但其功能和作用尚不清楚。在此，我们研究了FOXL2在卵泡发生和卵巢颗粒细胞类固醇合成中的生理作用。我们阐明了FOXL2与性别、类固醇激素和卵泡发生相关的靶基因，并且FOXL2被证明在靶基因启动子中发挥转录因子的作用。因此，FOXL2在卵巢功能的调节中起着至关重要的作用。

The physiological role of FOXL2 in human granulosa and luteal cellsFOXL2, a forkhead transcription factor gene, have recently been demonstrated to be causative to granulosa cell tumor or primary ovarian failure. FOXL2 is expressed mostly in periocular and ovarian granulosa cells but its function and role remain unknown. Herein we investigated the physiological role of FOXL2 in folliculogenesis and steroidogenesis by ovarian granulosa cells. We clarified the target genes of FOXL2 that are related to sex steroidogenesis and folliculogenesis and FOXL2 is shown to play as a transcription factor in target gene promoters. Thus, FOXL2 is shown to be crucial in the regulationof ovarian function.