The importance of fetal antigen specific regulatory T cells in allogeneic pregnancy

调节性T（Treg）细胞在诱导胎母耐受中起重要作用。为了了解复发性妊娠丢失和着床失败的病因不明的病理生理，我们利用小鼠模型研究了父亲（胎儿）抗原特异性Treg细胞。父本抗原特异性Treg细胞具有父本抗原特异性免疫抑制活性。此外，异体妊娠小鼠着床前引流淋巴结和着床后子宫内父本抗原特异性Treg细胞增加，而同基因妊娠小鼠则没有。

Regulatory T（Treg） cells play an essential role for induction of feto-maternal tolerance. To understand the pathophysiology of unknown etiology of recurrent pregnancy loss and implantation failure, we have studied the paternal（fetal)antigen-specific Treg cells using mouse model. Paternal antigen specific Treg cells had paternal antigen specific immunosuppressive activity. Furthermore, paternal antigen specific Treg cells increased in the draining lymph nodes just before implantation , and in the uterus after implantation in allogeneic pregnant mice, but not in syngeneic pregnant mice.