Significance of endoplasmic reticulum stress in endometriosis as a chronic inflammatory disease

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In patients with endometriosis, the endoplasmic reticulum stress in endometrial tissue is different from the normal women. Difference of endoplasmic reticulum stress is also detected between the endometriosis tissue and the endometrial tissue. In endometriotic and endometrial stromal cells, endoplasmic reticulum stress induced chronic inflammatory cytokine, which induced further endoplasmic reticulum stress, resulted in endometriosis progression. In endometriotic stromal cells, chronic inflammation and Th2 immunological effect synergistically induced estron production, which also suggested to exacerbate the disease.