Analysis of the molecular mechanism of flip-flop that regulates the asymmetric distribution of lipids in the plasma membranes

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An adaptor protein was identified as the responsible factor of the mutant which was thought to have a defect of flip-flop machinery. The results of the RNAi experiment suggested the possibility that the adaptor protein contributes to the regulation of transbilayer movement of phosphatidylserine at the plasma membranes. I tried to identify the molecules which take part in the flip-flop machinery in cooperation with the adaptor protein. However, it has not succeeded yet. I also analyzed the signaling pathway involved in flip-flop machinery, and the relationship between flip-flop and cytoskeleton was implied.