Development of novel composite tissue allograft models using supermicrosurgery

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Novel composite tissue allograft animal models were developed using the supermicrosurgical techniques. We focused on mainly two models as follows; eye transplantation model using rabbits and uterus transplantation model using cynomolgus monkeys. Several problems in application of these models to clinical cases were noted such as optic nerve regeneration in eye model and pregnancy in uterus model, and thus several experiments were performed to solve these problems.