Creation of Dynamical Biosensor and Photothermal Conversion Materials by Light-induced force

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The aim of this study is the development of bottom-up fabrication of nanocomposites by the light irradiation and the chemical surface modification, which would contribute to nano-bioscience. By irradiating doughnut-shaped laser beam on the dispersion liquid of Ag nanoparticles (NPs) with various shapes, we have theoretically and experimentally demonstrated selective assembling of NPs with highly uniform size and shape. It is expected that such a control of uniformity of NPs can be utilized in wide research fields, for example, the property control of photoresponsive NPs for the highly sensitive biosensor and the medical application. Furthermore, we have succeeded in the detection of a small amount of heat coagulation proteins by probe particles with high photothermal effect, and have succeeded in the destruction of pathogenetic cells by optimized photothermogenetic metallic NPs.