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Plasma ATP triggers inflammation in SIRS

Plasma ATP triggers inflammation in SIRS
血浆 ATP 引发 SIRS 炎症
批准号:
23792086
负责人:
SUMI YUKA
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
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英文摘要
In systemic inflammatory syndrome response (SIRS) patients, plasma ATP levels were significantly higher than healthy controls (HC). Among SIRS, in post cardiac arrest syndrome (PCAS) patients, that whole-body ischemic reperfusion injury causes inflammation, plasma ATP was higher in non-survivors compared to survivors and HC. Besides, the ATP levels in PCAS correlate with APACHE score. In sepsis patients, neutrophil activation (CD11b expression) was significantly higher than in HC and the mean florescence intensity of CD11b correlates with plasma ATP. These data suggest that ATP release from damaged cells or activated inflammatory cells stimulates neutrophils via ATP receptors and triggers inflammation in SIRS.
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Plasma ATP levels and outcome of sepsis
血浆 ATP 水平和脓毒症的结果
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [末吉孝一郎, 角由佳, 角由佳, 角由佳, 角由佳]
通讯作者: 角由佳
Leukocyte deformability is a novel biomarker to reflect sepsis-induced disseminated intravascular coagulation
白细胞变形能力是反映脓毒症引起的弥散性血管内凝血的新型生物标志物
DOI: 10.1002/ams2.54
发表时间: 2015
期刊: Acute Medicine & Surgery
影响因子: 1.6
作者: [Morikawa M, Inoue Y, Sumi Y, Kuroda Y, Tanaka H.]
通讯作者: Tanaka H.
Fluorescence Imaging of ATP in Human Neutrophils with Organelle-Localizable Fluorescent Chemosensors
使用细胞器定位荧光化学传感器对人中性粒细胞中的 ATP 进行荧光成像
DOI: --
发表时间: 2014
期刊:
影响因子: --
作者: [末吉孝一郎, 角由佳]
通讯作者: 角由佳
Plasma ATP in SIRS patients
SIRS 患者的血浆 ATP
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [末吉孝一郎, 角由佳, 角由佳]
通讯作者: 角由佳
13
    ATP/adenosine balance in SIRS
    • 批准号:
      25462830
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.16万
    • 财政年份:
      2013
    • 负责人:
      SUMI YUKA
    • 依托单位:
    海外基金