Human applications and the comprehensive search of the metabolic syndrome specific proteins using saliva

建立高血压、高脂血症、糖尿病代谢综合征大鼠模型。我们通过测量这些模型大鼠唾液的成分来研究标记物。另外，收集高脂血症模型大鼠的唾液，进行唾液蛋白质组学分析。结果，高脂血症大鼠的唾液中，与对照组大鼠相比，有25种蛋白质在两者中的表达差异为2倍或更多。此外，我们发现有八种类型的新蛋白质的表达从这些结果。为了确定适用于人类的蛋白质分析，在这些大鼠的结果中鉴定的蛋白质中促进了对人类应用的研究。

We conducted the creation of rats model of metabolic syndrome of hypertension, hyperlipidemia and diabetes. We investigated the marker substances by measuring the components of the saliva in these model rats. In addition, we collected saliva of hyperlipidemia model rat, and then performed saliva proteome analysis. As a result, the saliva of hyperlipidemia rats, as compared with rats in the control group, there were 25 kinds of protein that had differences in expression 2-fold or more in both. In addition, we found that there were eight types of expression of novel proteins from these results. To determine the applicable protein analysis of human among the proteins identified in the results of these rats was promoted research for the application of human.