The role of glial cells in inflammatory pain and neuropathic pain of mental nerve area.

本研究采用精神神经松散结扎大鼠神经性疼痛模型和精神神经横断大鼠痛觉减退模型。观察Iba1免疫反应细胞和卫星细胞在三叉神经节中的行为。在两种模型中，Iba1免疫反应细胞数量增加，卫星细胞形态学改变，表现为细胞质变性和棘伸长。神经损伤后，神经元与卫星细胞间有较宽的间隙。损伤后4周，这一变化在两种模型中均持续存在，并且在痛觉减退模型大鼠中观察到神经元和卫星细胞的细胞死亡。

In this study, we used the neuropathic pain model rat which mental nerve was loosely ligated and the hypoalgesia model rat which mental nerve was transected. The behavior of Iba1 immunoreactive cells and satellite cells in the trigeminal ganglion was observed. In both models, the number of Iba1 immunoreactive cells was increased and morphological alteration of satellite cells was observed that was represented by degeneration of cytoplasm and extended spines. After nerve injury the wide space between neuron and satellite cells was observed. Four weeks after injury, this change was sustained in both models, and in addition the cell death of neurons and satellite cells was observed in the hypoalgesia model rat.