The role of glial cells in inflammatory pain and neuropathic pain of mental nerve area.

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In this study, we used the neuropathic pain model rat which mental nerve was loosely ligated and the hypoalgesia model rat which mental nerve was transected. The behavior of Iba1 immunoreactive cells and satellite cells in the trigeminal ganglion was observed. In both models, the number of Iba1 immunoreactive cells was increased and morphological alteration of satellite cells was observed that was represented by degeneration of cytoplasm and extended spines. After nerve injury the wide space between neuron and satellite cells was observed. Four weeks after injury, this change was sustained in both models, and in addition the cell death of neurons and satellite cells was observed in the hypoalgesia model rat.