Analysis of the establishment and the resistance mechanism of the Docetaxel-resistant oral squamous cell carcinoma

多西紫杉醇耐药口腔鳞癌的产生及耐药机制分析

• 批准号: 23792351
• 负责人: TAKAMARU Natsumi
• 金额: $ 2.66万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792351/
• 关键词: 耐性株; DOC; 口腔扁平上皮癌

We used B88 cell and CAL27 cell line which were the culture human oral squamous cell carcinoma cell line which we established in our classroom. Cancer cells to use in this study confirmed that a cell proliferation was inhibited by DOC and we gave DOC 1,10,100,1000pg/ml and sequential level and cultured both cells and manufactured cell line indicating the resistance in DOC. Both cells raise the density of DOC and treat it, and the cancer cells indicating the DOC resistance are establishing it than parent cells.

本实验采用我们在实验室建立的人口腔鳞癌细胞系B88细胞和CAL 27细胞。在本研究中使用的癌细胞证实了细胞增殖被DOC抑制，并且我们给予DOC 1、10、100、1000 pg/ml和连续水平，并培养两种细胞和制造的细胞系，表明DOC中的抗性。两种细胞都提高DOC的密度并对其进行处理，并且指示DOC抗性的癌细胞比亲本细胞建立DOC抗性。