Development of combined therapy of oral cancer of which molecular target survivin and NF-・B

[结果]survivin在口腔鳞癌患者中的表达率为88%。survivin的定位分为细胞核与细胞质阳性型、细胞质阴性型、细胞核与细胞质阳性型和细胞核与细胞质阴性型三大类。癌组织中survivin的表达与分化程度无相关性，但与侵袭型、Yamamoto-Kohama分型的核survivin表达有相关性。[结论]survivin在口腔鳞状细胞癌中的表达及表达水平的升高与侵袭方式有关。

[Result] Rate of survivin expression in oral squamous cell carcinoma patients was 88%. localization of survivin is a positive-type nucleus and cytoplasm, cytoplasm negative nucleus-positive type and negative-type nucleus and the cytoplasm, was classified into three groups. Between the degree of differentiation and the expression of survivin in cancer was not associated, but showed a correlation between nuclear survivin expression in invasion style, Yamamoto-Kohama classification.[Conclusion] Expression of survivin in oral squamous cell carcinoma and enhance its level of expression was suggested to be related to invasion style.