Autograft experiment of the induced bone on the periosteumby the supersonic and partial dissolution - precipitation HAp/BMP-2

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The hydroxyapatite modified by a partial dissolution-precipitation technique using supersonic treatment might be improved the ability of hard tissue induction with BMP-2. But, on this processing condition, bone formation takes time and the hydroxyapatite was not absorbed all even after nine month. In addition, it was suggested to insert the hydroxyapatite alone induced a new bone on the priosteum of the small animal such as the rat. Because a bony bridge formation between the new bone and the skull was not made, it was thought that the new bone on the periosteum could be removed easily and used for the bone graft.