Functional analysis of BMP-3b as a novel adipocytokine
Functional analysis of BMP-3b as a novel adipocytokine
批准号:
20591107
负责人:
HINO Jun
金额:
$3.0万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
We originally isolated BMP-3b,which inhibited osteogenesis, from bone tissue. BMP-3b is strongly expressed not only in the bone but also in adipose tissue. However, the function of BMP-3b in adipose tissue is still unknown. Recent studies show that adipocytokine, which exists in adipose tissue, is involved in metabolic syndrome or its related diseases. We performed functional analysis of BMP-3b in adipose tissue, which demonstrated that BMP-3b acts as a novel adipocytokine that inhibits adipogenesis and its secreted molecular form is a unique complex.
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BMP-3b過剰発現マウスを用いた脂肪組織における機能解析
使用 BMP-3b 过表达小鼠进行脂肪组织功能分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Tokudome T, Kishimoto I, Horio T, Arai Y, Schwenke DO, Hino J, Okano I, Kawano Y, Kohno M, Miyazato M, Nakao K, Kangawa K., 日野純]
通讯作者:
日野純
Bone morphogenetic protein-3b(BMP-3b)is an adipocytokine secreted from preadipocytes and inhibits their differentiation.
骨形态发生蛋白-3b(BMP-3b)是前脂肪细胞分泌的一种脂肪细胞因子,抑制其分化。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Tokudome T, Kishimoto I, Horio T, Arai Y, Schwenke DO, Hino J, Okano I, Kawano Y, Kohno M, Miyazato M, Nakao K, Kangawa K., 日野純, 日野純, 日野純, 日野純, 日野純, 日野純]
通讯作者:
日野純
DOI:
10.1038/ijo.2011.124
发表时间:
2012-05
期刊:
INTERNATIONAL JOURNAL OF OBESITY
影响因子:
4.9
作者:
[Hino, J., Miyazawa, T., Miyazato, M., Kangawa, K.]
通讯作者:
Kangawa, K.
BMP-3b functions as a novel adipocytokine that inhibits adipocyte differentiation by its unique complex
BMP-3b 作为一种新型脂肪细胞因子,通过其独特的复合物抑制脂肪细胞分化
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Tokudome T, Kishimoto I, Horio T, Arai Y, Schwenke DO, Hino J, Okano I, Kawano Y, Kohno M, Miyazato M, Nakao K, Kangawa K., 日野純, 日野純, 日野純]
通讯作者:
日野純
Bone morphogenetic protein-3b (BMP-3b) is an adipocytokine secreted from preadipocytes and inhibits their differentiation
骨形态发生蛋白-3b (BMP-3b) 是一种由前脂肪细胞分泌的脂肪细胞因子,可抑制其分化
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Tokudome T, Kishimoto I, Horio T, Arai Y, Schwenke DO, Hino J, Okano I, Kawano Y, Kohno M, Miyazato M, Nakao K, Kangawa K., 日野純, 日野純, 日野純, 日野純, 日野純]
通讯作者:
日野純
共 9 条
Autograft experiment of the induced bone on the periosteumby the supersonic and partial dissolution - precipitation HAp/BMP-2
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批准号:23792378
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.16万
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财政年份:2011
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负责人:HINO Jun
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依托单位:
Autograft experiment of the induced bone on the periosteum by absorptive HAp/BMP-2 to mandibular resected region.
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批准号:21792027
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.58万
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财政年份:2009
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负责人:HINO Jun
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依托单位:
Physiological and pathological analysis of BMP-3b in cardiovascular system.
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批准号:18590830
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.41万
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财政年份:2006
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负责人:HINO Jun
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依托单位:
The search for novel biologically active peptides that control bone metabolism.
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批准号:14571413
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2002
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负责人:HINO Jun
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依托单位:
海外基金