Autograft experiment of the induced bone on the periosteum by absorptive HAp/BMP-2 to mandibular resected region.

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The supra-periosteal implant, of the biomimctic functionally graded hydroxyapatite (fg-HAp, absorptive HAp)/BMP-2 showed high cell proliferation activity and excellent hard tissue induction. Moreover, it was suggested that the surrounding tissue become a periosteum according to the progress of the bone formation. In addition, the hydroxyapatite modified by a partial dissolution-precipitation technique using supersonic treatment might be improved the ability of hard tissue induction with BMP-2. Because a bony bridge formation between the new bone and the skull was not made, it was thought that the new bone on the periosteum could be removed easily and used for the bone graft.