The effects of midazolam and flumazenil on cerebral autoregulation

本研究观察咪达唑仑镇静后应用氟马西尼对脑循环的影响。给予氟马西尼后，咪达唑仑镇静所增强的脑自动调节功能没有改变。此外，单独服用氟马西尼改善了脑自动调节，减少了脑血流量。以上结果提示，氟马西尼不能拮抗咪达唑仑的脑循环作用，但可引起脑血流轻微下降，引起脑自主调节功能改变。

The present study investigated the effects of flumazenil administration after midazolam sedation on cerebral circulation. After flumazenil administration, the augmented cerebral autoregulation due to midazolam sedation did not change. Also, sole administration of flumazenil improved cerebral autoregulation with decreases in cerebral blood flow. These results suggested that flumazenil dose not antagonize the effects of cerebral circulation with midazolam, and induces altered cerebral autoregulation with slight decrease in cerebral blood flow.