The association between serum antibody to the periodontal pathogen and chronic kidney disease

肾脏疾病是公认的全球性健康问题；据估计，仅在日本，慢性肾脏疾病（CKD）患者就有1330万人，占日本人口的12.9%。本研究的目的是调查日本个体牙周病原体血清抗体与CKD之间的关系。数据来自215名79岁的参与者。在控制了其他重要的健康特征后，我们观察到血清牙龈卟啉卟啉菌抗体滴度升高与肾功能下降之间存在显著关联。本研究的结果表明，在社区为基础的日本老年人队列中，血清牙龈卟啉单胞菌抗体滴度升高与肾功能下降之间存在显著关联。未来的研究应该评估牙周治疗在降低CKD发生或进展风险方面的作用。

Kidney disease is recognized as a global health problem; the estimated number of the people with chronic kidney disease (CKD) in Japan alone is 13.3 million, which represents 12.9% of the population. The aim of this study was to investigate the association between serum antibody to the periodontal pathogen and CKD in Japanese individuals. Data were available from 215 participants aged 79 yrs. We observed a significant association between elevated serum antibody titer to P. gingivalis and decreased kidney function, after controlling for other important health characteristics. The findings of the present study suggest that there is a significant association between elevated serum antibody titer to P. gingivalis and decreased kidney function in the community-based cohort of elderly Japanese. Future studies should evaluate the contribution of periodontal therapy in reducing the risk for the development or progression of CKD.