Application of side-chain cross-linked helical peptides having photoreactive groups to biotools

基于DNA结合蛋白的结合结构域，我开发了以二芳基乙烯为基础的交联剂桥连的光响应螺旋肽。石英晶体微天平（QCM）分析表明，实时监测，DNA-肽相互作用的光调节与荧光灯。此外，开发了基于二芳基乙烯的非天然氨基酸并将其引入短肽中。

I developed photoresponsive helical peptides bridged with a diarylethene-based cross-linking agenet on the basis of the binding domains of DNA-binding proteins. Quartz crystal microbalance (QCM) analysis showed real-time monitoring that DNA-peptide interaction was photoregulated with a fluorescent lamp. Additionally, diarylethene-based non-natural amino acids were developed and were introduced into shortpeptides.