Synthesis and characterization of layered double hydroxide nanosphere and its application for novel drug delivery material

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Layered double hydroxide (LDH) has been considerable attentions as materials for drug delivery in pharmaceutical field. In this study, the synthesis of LDH nanosphere (LDH-NS) by using carbon nanosphere template and the intercalation of anticancer drug, 5-fluorouracil (5-FU), into the LDH-NS by the reconstruction method have been investigated in order to promote the cellular uptake of 5-FU. The XRD patterns of the 5-FU/LDH-NS showed that the interlayer distance was expanded with the intercalation of 5-FU. The results of HeLa cytotoxicity assay indicated that the 5-FU/LDH-NS performed well cytostatic effect, which is three times higher than that of 5-FU.