Gene carriers containing functional peptides for breast cancer treatment

含有肿瘤归宿多肽的纳米级融合多肽与质粒DNA(PDNA)的复合体被设计为细胞毒性较低和高度靶向性的基因载体。含有Lyp1的融合多肽与含有F3的融合多肽对MCF10A细胞的杀伤作用有显著差异，因此含有F3的融合多肽被认为是最有价值的靶向致瘤细胞的候选多肽。PDNA复合体对肿瘤细胞的靶向性也被发现通过细胞表面的特定吸附过程来调节。

Nano-scale complexes of fusion peptides to contain tumor homing peptides with plasmid DNA (pDNA) are designed as less-cytotoxic and highly target-specific gene carriers. The fusion peptide containing Lyp1 showed significant differences from fusion peptide containing F3 in cytotoxicity to MCF10A cells, and the fusion peptide containing F3 is therefore considered to be the most useful candidate for target delivery into tumorigenic cells. The target specificity of the pDNA complexes to tumorigenic cells was also found to be regulated by specific adsorption process on the cell surface.