Chemical biology approach to ganglioside-induced amyloidosis

β淀粉样蛋白是阿尔茨海默病的致病因子，众所周知，β淀粉样蛋白通过与神经节苷脂GM1结合形成聚集体成核，这种成核可能在体内增强β淀粉样蛋白的聚集。本研究研究了基于GM1结构的非天然形式神经节苷脂的合成，以阐明神经节苷脂与β淀粉样蛋白的相互作用。采用click化学方法对具有活性位点的gm1型聚糖的合成途径进行了研究，得到了最佳的合成方法。

Amyloid beta which is causative agent of Alzheimer's disease is widely known to form aggregate nucleation by binding with ganglioside GM1, and this nucleation is suggested to enhance aggregation of amyloid beta in vivo. In this study, the synthesis of non-native form ganglioside based on GM1 structure was investigated to clarify the interaction between ganglioside and amyloid beta. We examined synthesis pathway of GM1-type glycan which possess reactive site by click chemistry, and obtained optimal synthesis method.