Structural analysis of the Rab and SNARE localization
Structural analysis of the Rab and SNARE localization
Rab 和 SNARE 定位的结构分析
批准号：
23770107
负责人：
ITO Sakurako
金额：
$2.91万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2012
中文摘要
翻译
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英文摘要
In eukaryotic cells, Rab and SNARE regulate the fusion of membrane compartments. Rabs are inseted into membranes via the prenylated moieties which are post-translationally attached. A membrane protein called GDF is proposed to catalyze the membrane insertion of Rab. As GDF and VAMP2, one of the SNARE protein, is shown to interact with each other, we are trying to reveal the structural basis of GDF-SNARE cooperation. So far, we have succeeded in the crystallization of GDF, and now trying to improve thediffraction quality of crystals. Also, we are trying to prepare GDF-VAMP2 complex.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Get3 による翻訳後膜埋込み機構の構造学的基盤
Get3翻译后膜嵌入机制的结构基础
Get3翻译后膜嵌入机制的结构基础
DOI：
--
发表时间：
2012
期刊：
影响因子：
--
作者：
[Saito, N., 山形敦史]
通讯作者：
山形敦史
DOI：
10.1002/prot.24273
发表时间：
2013-07-01
期刊：
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
影响因子：
2.9
作者：
[Nakagawa, Hirofumi, Kuratani, Mitsuo, Yokoyama, Shigeyuki]
通讯作者：
Yokoyama, Shigeyuki
Structural analysis of novel RabGEF proteins
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批准号：17K15072
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项目类别：Grant-in-Aid for Young Scientists (B)
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资助金额：$2.91万
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财政年份：2017
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负责人：ITO Sakurako
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依托单位：
Analysis of Rab membrane insertion mechanism using artificial membranes
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批准号：25650018
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项目类别：Grant-in-Aid for Challenging Exploratory Research
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资助金额：$2.58万
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财政年份：2013
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负责人：ITO Sakurako
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依托单位：
海外基金
