Studying on ppGalNAcT with focus on the roles of mucin-type carbohydrates in the retinal development.

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We cloned and identified 18 genes encoding ppGalNAcT from zebrafish cDNA library, corresponding to 20 isozymes in human genome. Then, we detected their mRNAs in the embryos during early developmental stages, and found that each of members has characteristic expression patterns mainly in eye, brain and skeletal muscle. Suppression of ppGalNAcT17 and T18 using antisense RNA led to developmental defects in the central nervous system and tail, respectively.