Impact of endothelin-1 on bovine pregnancy: possible involvement of local regulation system of placental function

点击翻译按钮获取中文摘要

Endothelin-1 (ET-1) is known as a most potent vasoconstrictor and participates in feto-placental growth and development during pregnancy. The aim of this study was to investigate physiological role of ET-1 in the regulation of placental function during pregnancy in cattle. The results of present study demonstrate that ET-1 is locally produced in bovine placenta and secreted into maternal circulation during pregnancy. In addition, ET-1 interacts with various vasoactive peptides, angiogenic factors and placental hormones within bovine placenta. These findings suggest a crucial role of ET-1 in the regulation of placental function and involvement of vasoactive substances including ET-1 on maintenance of bovine pregnancy.