Impact of endothelin-1 on bovine pregnancy: possible involvement of local regulation system of placental function

内皮素-1对牛妊娠的影响：可能涉及胎盘功能的局部调节系统

• 批准号: 23780284
• 负责人: HAYASHI Kengo
• 金额: $ 2.91万
• 依托单位: National Institute of Agrobiological Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23780284/
• 关键词: ウシ; 胎盤; 妊娠; エンドセリン; エンドセリン1; 血管作動性物質

Endothelin-1 (ET-1) is known as a most potent vasoconstrictor and participates in feto-placental growth and development during pregnancy. The aim of this study was to investigate physiological role of ET-1 in the regulation of placental function during pregnancy in cattle. The results of present study demonstrate that ET-1 is locally produced in bovine placenta and secreted into maternal circulation during pregnancy. In addition, ET-1 interacts with various vasoactive peptides, angiogenic factors and placental hormones within bovine placenta. These findings suggest a crucial role of ET-1 in the regulation of placental function and involvement of vasoactive substances including ET-1 on maintenance of bovine pregnancy.

内皮素-1 （ET-1）被认为是一种最有效的血管收缩剂，在怀孕期间参与胎儿-胎盘的生长发育。本研究旨在探讨ET-1在奶牛妊娠期胎盘功能调节中的生理作用。本研究结果表明，ET-1在牛胎盘中局部产生，并在怀孕期间分泌到母体循环中。此外，ET-1在牛胎盘中与多种血管活性肽、血管生成因子和胎盘激素相互作用。这些发现表明ET-1在胎盘功能的调节中起着至关重要的作用，并且包括ET-1在内的血管活性物质参与维持牛妊娠。

项目成果

Placental expression and localization of endothelin-1 system and nitric oxide synthases during bovine pregnancy.

牛妊娠期间内皮素-1系统和一氧化氮合酶的胎盘表达和定位。

• 发表时间: 2012
• 期刊: Animal Reproduction Science
• 影响因子: 2.2
• 作者: Ken;M. Hosoe;Toru Takahashi
• 通讯作者: Toru Takahashi

ウシ妊娠期間中の子宮および胎盤におけるアドレノメデュリンの遺伝子発現動態と局在の解析

牛妊娠期子宫和胎盘中肾上腺髓质素基因表达动态及定位分析

• 发表时间: 2011
• 作者: 林憲悟;細江実佐;高橋透
• 通讯作者: 高橋透

Placental expression and localization of adrenomedullin system during bovine pregnancy

牛妊娠期间肾上腺髓质素系统的胎盘表达和定位

• 发表时间: 2011
• 作者: Hayashi KG;Hosoe M;Takahashi T
• 通讯作者: Takahashi T