Research for reward-basis decision making in drug abuse-dependent rat

在目前的研究中，我们开发了一种使用放射臂迷宫的啮齿动物赌博测试，以解决药物依赖患者的决策问题。我们的发现表明，慢性甲基苯丙胺治疗可能会导致基于奖励的决策的改变。从岛叶皮质到纹状体的皮质-纹状体通路的异常激活可能与甲基苯丙胺依赖大鼠基于奖赏的决策障碍有关。

In the present study, we developed a gambling test for rodents using a radial-arm maze to address the issue of decision-making in patients with drug dependence. Our findings suggest that chronic methamphetamine treatment may lead to alternations of reward-based decision-making. Aberrant activation of the cortico-striatal pathway from insular cortex to striatum may be associated with the impairment of reward-based decision-making in methamphetamine-dependent rats.