Characterization of kidney specific organic anion transporter SLCO4C1

肾脏特异性有机阴离子转运蛋白 SLCO4C1 的表征

• 批准号: 23790168
• 负责人: YAMAGUCHI Hiroaki
• 金额: $ 2.75万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790168/
• 关键词: 薬物動態・代謝学; 異物排泄; トランスポーター; 腎臓

Novel substrates for SLCO4C1 were searched and the contribution of SLCO4C1 to the renal uptake of the substrates in renal proximal tubular epithelial cells HK-2 cells was examined. As results, quinolinic acid and indole-3-acetate were found as novel substrates for SLCO4C1. SLCO4C1 mainly contributes to renal uptake of digoxin and ouabain in HK-2 cells.

寻找SLCO4C1的新底物，并研究其对肾近端小管上皮细胞HK-2细胞摄取底物的贡献。结果发现，喹啉酸和吲哚-3-乙酸酯是SLCO4C1的新型底物。SLCO4C1主要参与HK-2细胞对地高辛和哇巴因的肾摄取。

项目成果

DCF療法における各抗がん薬血中濃度の解析

DCF治疗中各抗癌药物血药浓度分析

• 发表时间: 2012
• 作者: Misawa T;Hayashi H;Sugiyama Y;Hashimoto Y.;山口浩明
• 通讯作者: 山口浩明

A rapid and sensitive LC/ESI-MS/MS method for quantitative analysis of docetaxel in human plasma and its application to a pharmacokinetic study

• DOI: 10.1016/j.jchromb.2012.02.003
• 发表时间: 2012-04-15
• 期刊: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
• 影响因子: 3
• 作者: Yamaguchi, Hiroaki;Fujikawa, Asuka;Iseki, Ken
• 通讯作者: Iseki, Ken

スタチンの骨格筋障害に及ぼす酸・アルカリ化誘導剤の影響

酸/碱化诱导剂对他汀类药物所致骨骼肌损伤的影响

• 发表时间: 2012
• 期刊: YAKUGAKU ZASSHI
• 影响因子: 0.3
• 作者: 小林正紀;日高和宏;山口浩明ら;他6名
• 通讯作者: 他6名

The Decrease in Farnesoid X Receptor, Pregnane X Receptor and Constitutive Androstane Receptor in the Liver after Intestinal Ischemia-Reperfusion

• DOI: 10.18433/j38c88
• 发表时间: 2012-01-01
• 期刊: JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
• 影响因子: 2.7
• 作者: Ogura, Jiro;Terada, Yusuke;Iseki, Ken
• 通讯作者: Iseki, Ken

Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry

• DOI: 10.1007/s00216-012-6004-9
• 发表时间: 2012-06-01
• 期刊: ANALYTICAL AND BIOANALYTICAL CHEMISTRY
• 影响因子: 4.3
• 作者: Saigusa, Daisuke;Shiba, Kanako;Tomioka, Yoshihisa
• 通讯作者: Tomioka, Yoshihisa