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Involvement of intracellular vesicular trafficking in toxicity of anticancer drugs

Involvement of intracellular vesicular trafficking in toxicity of anticancer drugs
细胞内囊泡运输参与抗癌药物的毒性
批准号:
23790171
负责人:
TAKAHASHI Tsutomu
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

项目摘要

项目成果

TAKAHASHI Tsutomu的其他基金

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英文摘要
We examined the relationship between intracellular transport pathways and adriamycin toxicity, and found that defect of genes for endoplasmic reticulum (ER)-to-golgi transport enhanced adriamycin toxicity. We also found that disruption of Erv14, one of the cargo receptors involved in ER-to-golgi transport, conferred hypersensitivity to adriamycin. Our results suggest that Erv14 dependent ER-to-golgi transport system plays a major role in the defense mechanism against toxicity of adriamycin.
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Mevalonate pathway plays a major role in adriamycin resistance
甲羟戊酸途径在阿霉素耐药性中起主要作用
DOI: --
发表时间:
期刊:
影响因子: --
作者: [○高橋 勉, 中島伸吾, 増田拓朗, 米田茂広, 永沼 章]
通讯作者: 永沼 章
Overexpression of CLN1, CLN2, or ERG13 increases resistance to adriamycin in Saccharomyces cerevisiae
CLN1、CLN2 或 ERG13 的过度表达会增加酿酒酵母对阿霉素的耐药性
DOI: 10.2131/jts.36.855
发表时间: 2011
期刊: The Journal of Toxicological Sciences
影响因子: --
作者: [Takahashi T., Nakashima S., Masuda T., Yoneda S., Hwang G.W., Naganuma A.]
通讯作者: Naganuma A.
Overexpression of HMG-CoA synthase confers resistance to adriamycin in both yeast cells and mammalian cells
HMG-CoA 合酶的过度表达赋予酵母细胞和哺乳动物细胞对阿霉素的抗性
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [高橋勉 , 永沼章]
通讯作者: 永沼章
DOI: 10.1248/yakushi.12-00279
发表时间: 2013
期刊: YAKUGAKU ZASSHI
影响因子: 0.3
作者: [Sekine S, Kimura T, Motoyama M, Shitara Y, Wakazono H, Oida H, Horie T., 奈邉健,赤水希衣,藤田真理維,中川知美,塩江真代,藤井正徳,水谷暢明,吉野伸,DavidD.Chaplin., Takahashi T]
通讯作者: Takahashi T
6
    The Politics of Samuel Morse's Telegraph Sygnals
    • 批准号:
      19K00395
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.58万
    • 财政年份:
      2019
    • 负责人:
      TAKAHASHI Tsutomu
    • 依托单位:
    Concord Jeremiad: Thoreau's Rhetoric of the Age
    • 批准号:
      24520294
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.83万
    • 财政年份:
      2012
    • 负责人:
      TAKAHASHI Tsutomu
    • 依托单位:
    Disease specificity of the brain morphologic changes in psychiatric disorders
    • 批准号:
      22591275
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.83万
    • 财政年份:
      2010
    • 负责人:
      TAKAHASHI Tsutomu
    • 依托单位:
    ChiIdren Thoreau Loved : Transcendentalism and Educational Reforms
    • 批准号:
      21520262
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.5万
    • 财政年份:
      2009
    • 负责人:
      TAKAHASHI Tsutomu
    • 依托单位: