Involvement of intracellular vesicular trafficking in toxicity of anticancer drugs
Involvement of intracellular vesicular trafficking in toxicity of anticancer drugs
批准号:
23790171
负责人:
TAKAHASHI Tsutomu
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
We examined the relationship between intracellular transport pathways and adriamycin toxicity, and found that defect of genes for endoplasmic reticulum (ER)-to-golgi transport enhanced adriamycin toxicity. We also found that disruption of Erv14, one of the cargo receptors involved in ER-to-golgi transport, conferred hypersensitivity to adriamycin. Our results suggest that Erv14 dependent ER-to-golgi transport system plays a major role in the defense mechanism against toxicity of adriamycin.
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Mevalonate pathway plays a major role in adriamycin resistance
甲羟戊酸途径在阿霉素耐药性中起主要作用
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[○高橋 勉, 中島伸吾, 増田拓朗, 米田茂広, 永沼 章]
通讯作者:
永沼 章
Overexpression of CLN1, CLN2, or ERG13 increases resistance to adriamycin in Saccharomyces cerevisiae
CLN1、CLN2 或 ERG13 的过度表达会增加酿酒酵母对阿霉素的耐药性
DOI:
10.2131/jts.36.855
发表时间:
2011
期刊:
The Journal of Toxicological Sciences
影响因子:
--
作者:
[Takahashi T., Nakashima S., Masuda T., Yoneda S., Hwang G.W., Naganuma A.]
通讯作者:
Naganuma A.
Overexpression of HMG-CoA synthase confers resistance to adriamycin in both yeast cells and mammalian cells
HMG-CoA 合酶的过度表达赋予酵母细胞和哺乳动物细胞对阿霉素的抗性
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[高橋勉 , 永沼章]
通讯作者:
永沼章
A Screen for Genes Involved in Adriamycin Resistance in <i>Saccharomyces cerevisiae</i>
酿酒酵母阿霉素耐药基因的筛选
DOI:
10.1248/yakushi.12-00279
发表时间:
2013
期刊:
YAKUGAKU ZASSHI
影响因子:
0.3
作者:
[Sekine S, Kimura T, Motoyama M, Shitara Y, Wakazono H, Oida H, Horie T., 奈邉健,赤水希衣,藤田真理維,中川知美,塩江真代,藤井正徳,水谷暢明,吉野伸,DavidD.Chaplin., Takahashi T]
通讯作者:
Takahashi T
遺伝子ノックダウン酵母を用いた亜ヒ酸感受性に影響を与える遺伝子の検索
使用基因敲除酵母寻找影响亚砷酸盐敏感性的基因
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[佐竹翔平, 高橋勉, 永沼章]
通讯作者:
永沼章
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