Identification of the factor released from apoptotic cells that regulates the gene expressions in macrophages
Identification of the factor released from apoptotic cells that regulates the gene expressions in macrophages
批准号:
23790330
负责人:
YAMAGUCHI Hiroshi
金额:
$1.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
我发现凋亡细胞通过caspase切割的panx1通道释放AMP。此外,我发现释放的AMP在巨噬细胞上被CD73转化为腺苷,进而通过腺苷A2受体将免疫抑制信号转导到巨噬细胞。
英文摘要
I found that apoptotic cells released AMP via caspase cleaved-panx1 channel.Furthermore, I revealed that released AMP was converted to adenosine by CD73 on macrophages and, in turn, transduced the immunosuppressive signal to macrophages via adenosine A2 receptors.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Release by apoptotic cells of a factor(s) that regulates the gene expression in macrophages.
凋亡细胞释放调节巨噬细胞基因表达的因子。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Hiroshi Yamaguchi, Shigekazu Nagata]
通讯作者:
Shigekazu Nagata
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